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Learning from Trial Failures: Turning Setbacks into Strategic Data Assets

Every company has a “Phase III heartbreak.” The molecule looked perfect—mechanism sound, safety profile strong—but the primary endpoint missed. Most teams bury the data. At Octavus Consulting, we treat it as a gold mine. The Opportunity in Failure Clinical failures hold information about trial design, recruitment, and patient heterogeneity that can redefine the next success. […]
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Strategic Intelligence in Biopharma M&A: Seeing the Deal Before It Happens

When Gilead acquired Forty Seven Inc. in 2020, most observers called it quick. Those who tracked macrophage checkpoint research knew it was inevitable. That’s the power of strategic intelligence—not reacting to news, but foreseeing inevitabilities. At Octavus Consulting, we help clients move from rumor-driven scouting to pattern-based acquisition strategy. In 2025’s market—where capital discipline and […]
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Real-World Evidence 2.0: From Post-Market Validation to Strategic Design

In 2025, Real-World Evidence (RWE) is no longer an afterthought in regulatory filings. It’s a design principle. We recently worked with a biotech firm developing an oncology therapy struggling with limited trial enrollment and payer skepticism. Instead of waiting until post-launch to demonstrate real-world value, they embedded RWE from day one. By integrating claims and […]
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